Home Transmembrane Transporters Sodium Channel inhibitor Quinidine hemisulfate hydrate

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Quinidine hemisulfate hydrate Sodium Channel inhibitor

Cat.No.S3751

Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Quinidine hemisulfate hydrate Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 391.47

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Chemical Information, Storage & Stability

Molecular Weight 391.47 Formula

C20H24N2O2.1/2H2SO4.H2O

 Storage (From the date of receipt)
CAS No. 6591-63-5 Download SDF Storage of Stock Solutions

Synonyms Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O

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Mechanism of Action

Targets/IC50/Ki
Sodium channel [1]
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates[1].
In vivo

Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo[2].
References

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